- Mediastinal Glomus Tumor: A Case Report and Literature Review
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Si-Hyong Jang, Hyun Deuk Cho, Ji-Hye Lee, Hyun Ju Lee, Hae Yoen Jung, Kyung-Ju Kim, Sung Sik Cho, Mee-Hye Oh
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J Pathol Transl Med. 2015;49(6):520-524. Published online August 4, 2015
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DOI: https://doi.org/10.4132/jptm.2015.07.02
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- A glomus tumor in the mediastinum is very uncommon, and only five cases have been reported in the English literature. We recently encountered a 21-year-old woman with an asymptomatic mediastinal mass that measured 5.3 × 4.0 cm. Surgical excision was performed, and the tumor was finally diagnosed as mediastinal glomus tumor with an uncertain malignant potential. After reviewing this case and previous reports, we analyzed the clinicopathologic features associated with progression of such a tumor.
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- A case of mediastinal mesenchymal tumor with pericytic neoplasm feature that responded to radiation therapy
Miho Muramoto, Shintaro Kanda, Takashi Kobayashi, Hisashi Tamada, Ayumu Fukazawa, Keiichirou Koiwai, Tomonobu Koizumi Thoracic Cancer.2023; 14(13): 1204. CrossRef - Report of a vagal paraganglioma at the cervicothoracic junction
Jun Yun, Danielle Kapustin, Aisosa Omorogbe, Samuel J. Rubin, Daniel G. Nicastri, Reade A. De Leacy, Azita Khorsandi, Mark L. Urken Head & Neck.2023;[Epub] CrossRef - Total-Body Irradiation Is Associated With Increased Incidence of Mesenchymal Neoplasia in a Radiation Late Effects Cohort of Rhesus Macaques (Macaca mulatta)
W. Shane Sills, Janet A. Tooze, John D. Olson, David L. Caudell, Greg O. Dugan, Brendan J. Johnson, Nancy D. Kock, Rachel N. Andrews, George W. Schaaf, Richard A. Lang, J. Mark Cline International Journal of Radiation Oncology*Biology*Physics.2022; 113(3): 661. CrossRef - Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach
Joon Hyuk Choi, Jae Y. Ro Advances in Anatomic Pathology.2021; 28(5): 351. CrossRef - La glomangiomatose médiastinale postérieure : localisation exceptionnelle d’une tumeur rare. À propos d’un cas
A. Machboua, S. Hamraoui, S. Zarouki, I. Kamaoui, I. Alloubi Revue des Maladies Respiratoires.2021; 38(8): 848. CrossRef - An unusual case of chest wall glomus tumor presenting with axillary pain: a case report and literature review
Leila Oryadi Zanjani, Bahman Shafiee Nia, Farzad Vosoughi, Elham Mirzaian, Leila Aghaghazvini, Aidin Arabzadeh European Journal of Medical Research.2021;[Epub] CrossRef - Clinical Implications of 18F-FDG PET/CT in Malignant Glomus Tumors of the Esophagus
Romain-David Seban, Laurence Bozec, Laurence Champion Clinical Nuclear Medicine.2020; 45(6): e301. CrossRef - Symplastic glomus tumor of the urinary bladder treated by robot-assisted partial cystectomy: a case report and literature review
Franco Palmisano, Franco Gadda, Matteo G. Spinelli, Marco Maggioni, Bernardo Rocco, Emanuele Montanari Urologia Journal.2018; 85(3): 130. CrossRef - Thoracoscopic Surgery for Glomus Tumor: An Uncommon Mediastinal Neoplasm and Iatrogenic Tracheal Rupture
Zhongjie Fang, Dehua Ma, Baofu Chen, Huarong Luo Case Reports in Surgery.2017; 2017: 1. CrossRef - Asymptomatic Glomus Tumor of the Mediastinum
Meletios Kanakis, Nikoletta Rapti, Maria Chorti, Achilleas Lioulias Case Reports in Surgery.2015; 2015: 1. CrossRef
- A Rare Case of Primary Tubular Adenocarcinoma of the Thymus, Enteric Immunophenotype: A Case Study and Review of the Literature
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Hae Yoen Jung, Hyundeuk Cho, Jin-Haeng Chung, Sang Byoung Bae, Ji-Hye Lee, Hyun Ju Lee, Si-Hyong Jang, Mee-Hye Oh
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J Pathol Transl Med. 2015;49(4):331-334. Published online June 1, 2015
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DOI: https://doi.org/10.4132/jptm.2015.04.16
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8,585
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- Thymic carcinomas are uncommon malignant tumors, and thymic adenocarcinomas are extremely rare. Here, we describe a case of primary thymic adenocarcinoma in a 59-year-old woman. Histological examination of the tumor revealed tubular morphology with expression of cytokeratin 20 and caudal-type homeobox 2 according to immunohistochemistry, suggesting enteric features. Extensive clinical and radiological studies excluded the possibility of an extrathymic primary tumor. A review of the literature revealed only two global cases of primary tubular adenocarcinomas of the thymus with enteric immunophenotype.
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- Case report: Primary adenocarcinoma NOS of the thymus and cytological features
Jonathan Willner, Osvaldo Hernandez, Lea Azour, Andre L. Moreira Diagnostic Cytopathology.2023;[Epub] CrossRef - Enteric-type thymic adenocarcinoma: a case report and literature review focusing on prognosis based on histological subtypes
Rurika Hamanaka, Kei Nakano, Takaaki Tsuboi, Kazuhito Hatanaka, Mitsutomo Kohno, Ryota Masuda, Masayuki Iwazaki General Thoracic and Cardiovascular Surgery.2022; 70(5): 501. CrossRef - Metastatic thymic-enteric adenocarcinoma responding to chemoradiation plus anti-angiogenic therapy: A case report
Man Li, Xiao-Yu Pu, Li-Hua Dong, Peng-Yu Chang World Journal of Clinical Cases.2021; 9(7): 1676. CrossRef - A case report: primary thymic adenocarcinoma with enteric differentiation
Yuuki Kou, Hirokazu Tanaka, Nobuhisa Yamazaki, Hiroyoshi Watanabe, Makoto Sonobe The Journal of the Japanese Association for Chest Surgery.2020; 34(2): 107. CrossRef - Thymic enteric type adenocarcinoma: A case report with cytological features
Marie Tamai, Mitsuaki Ishida, Yusuke Ebisu, Hisashi Okamoto, Chika Miyasaka, Chisato Ohe, Yoshiko Uemura, Tomohito Saito, Tomohiro Murakawa, Koji Tsuta Diagnostic Cytopathology.2018; 46(1): 92. CrossRef - Histologic characteristics of thymic adenocarcinomas: Clinicopathologic study of a nine-case series and a review of the literature
Ah-Young Kwon, Joungho Han, Jinah Chu, Yong Soo Choi, Byeong-Ho Jeong, Myung-Ju Ahn, Yong Chan Ahn Pathology - Research and Practice.2017; 213(2): 106. CrossRef - Characterization of genetic aberrations in a single case of metastatic thymic adenocarcinoma
Yeonghun Lee, Sehhoon Park, Se-Hoon Lee, Hyunju Lee BMC Cancer.2017;[Epub] CrossRef - Cytologic Characteristics of Thymic Adenocarcinoma with Enteric Differentiation: A Study of Four Fine-Needle Aspiration Specimens
Ah-Young Kwon, Joungho Han, Hae-yon Cho, Seokhwi Kim, Heejin Bang, Jiyeon Hyeon Journal of Pathology and Translational Medicine.2017; 51(5): 509. CrossRef - Mucinous cystic tumor with CK20 and CDX2 expression of the thymus: Is this a benign counterpart of adenocarcinoma of the thymus, enteric type?
Jun Akiba, Hiroshi Harada, Shintaro Yokoyama, Toshihiro Hashiguchi, Akihiko Kawahara, Masahiro Mitsuoka, Shinzo Takamori, Hirohisa Yano Pathology International.2016; 66(1): 29. CrossRef - Colon cancer chemotherapy for a patient with CDX2-expressing metastatic thymic adenocarcinoma: a case report and literature review
Akihiko Sawaki, Mikiya Ishihara, Yuji Kozuka, Hiroyasu Oda, Satoshi Tamaru, Yumiko Sugawara, Yoshiki Yamashita, Toshiro Mizuno, Taizo Shiraishi, Naoyuki Katayama International Cancer Conference Journal.2016; 5(2): 113. CrossRef - Metastatic Thymic Adenocarcinoma from Colorectal Cancer
Mina Lee, Suk Jin Choi, Yong Han Yoon, Joung-Taek Kim, Wan Ki Baek, Young Sam Kim The Korean Journal of Thoracic and Cardiovascular Surgery.2015; 48(6): 447. CrossRef
- Clinicopathologic Implication of Ezrin Expression in Non-small Cell Lung Cancer
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Ho Won Lee, Eui Han Kim, Mee-Hye Oh
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Korean J Pathol. 2012;46(5):470-477. Published online October 25, 2012
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DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.5.470
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8,182
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- Background
Ezrin, a member of the ezrin-radixin-moesin family, is implicated in tumor progression, metastatic dissemination, and adverse outcomes, in several cancer types. In this study, we explored the clinicopathological significance of ezrin expression in non-small cell lung carcinomas (NSCLCs). MethodsImmunohistochemical analysis of tissue microarray with 112 surgically resected NSCLC specimens, was performed to examine the ezrin expression. We also correlated ezrin expression with other clinicopathological features and prognosis. ResultsThe ezrin-positive group revealed significantly higher correlation with pleural invasion (p=0.016) and pathologic stage (p=0.050). Univariate survival analysis showed that ezrin-positive group had a significantly shorter cancer-specific survival than ezrin-negative group (p=0.016). Meanwhile, female (p=0.030), no pleural invasion (p=0.023), no lymphatic invasion (p=0.026), and early pathologic stage (p=0.008) significantly correlated with longer survival. Multivariate survival analysis showed that variables such as ezrin positivity (p=0.032), female (p=0.035), and early pathologic stage (p=0.001) were independent prognostic factors for NSCLC. ConclusionsEzrin might be a molecular marker to predict poor prognosis of NSCLC.
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- Perspectives for Targeting Ezrin in Cancer Development and Progression
Jean Carlos Lipreri da Silva, Hugo Passos Vicari, João Agostinho Machado-Neto Future Pharmacology.2023; 3(1): 61. CrossRef - CIGB-300 Anticancer Peptide Differentially Interacts with CK2 Subunits and Regulates Specific Signaling Mediators in a Highly Sensitive Large Cell Lung Carcinoma Cell Model
George V. Pérez, Mauro Rosales, Ailyn C. Ramón, Arielis Rodríguez-Ulloa, Vladimir Besada, Luis J. González, Daylen Aguilar, Dania Vázquez-Blomquist, Viviana Falcón, Evelin Caballero, Paulo C. Carvalho, Rodrigo Soares Caldeira, Ke Yang, Yasser Perera, Silv Biomedicines.2022; 11(1): 43. CrossRef - Increased Tumor Growth Rate and Mesenchymal Properties of NSCLC-Patient-Derived Xenograft Models during Serial Transplantation
José Miguel Pardo-Sánchez, Nuria Mancheño, José Cerón, Carlos Jordá, Emilio Ansotegui, Óscar Juan, Sarai Palanca, Antonio Cremades, Carolina Gandía, Rosa Farràs Cancers.2021; 13(12): 2980. CrossRef - Loss of ARID1A expression is associated with poor prognosis in non-small cell lung cancer
Si-Hyong Jang, Ji-Hye Lee, Hyun Ju Lee, Hyundeuk Cho, Hyein Ahn, In Hag Song, Mee-Hye Oh Pathology - Research and Practice.2020; 216(11): 153156. CrossRef - Ezrin Mediates Invasion and Metastasis in Tumorigenesis: A Review
Yanan Song, Xiaokun Ma, Miao Zhang, Menghan Wang, Guoyu Wang, Ying Ye, Wei Xia Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef - Correlation of Ezrin Expression Pattern and Clinical Outcomes in Ewing Sarcoma
Thomas Cash, Hong Yin, Courtney McCracken, Zhi Geng, Steven G. DuBois, Bahig M. Shehata, Thomas A. Olson, Howard M. Katzenstein, Cynthia Wetmore Sarcoma.2017; 2017: 1. CrossRef - Prognostic and Clinicopathological Significance of Transducer-Like Enhancer of Split 1 Expression in Gastric Cancer
Ji-Hye Lee, Myoung-Won Son, Kyung-Ju Kim, Mee-Hye Oh, Hyundeuk Cho, Hyun Ju Lee, Si-Hyong Jang, Moon Soo Lee Journal of Gastric Cancer.2016; 16(1): 21. CrossRef - Significance of DEK overexpression for the prognostic evaluation of non-small cell lung carcinoma
XIN LIU, DONGDONG QI, JUJIE QI, ZESHU MAO, XIANGDAN LI, JINHUI ZHANG, JINZI LI, WENBIN GAO Oncology Reports.2016; 35(1): 155. CrossRef - Silencing of high‐mobility group box 2 (HMGB2) modulates cisplatin and 5‐fluorouracil sensitivity in head and neck squamous cell carcinoma
Nazia Syed, Sandip Chavan, Nandini A. Sahasrabuddhe, Santosh Renuse, Gajanan Sathe, Vishalakshi Nanjappa, Aneesha Radhakrishnan, Remya Raja, Sneha M. Pinto, Anand Srinivasan, T. S. Keshava Prasad, Kotteazeth Srikumar, Harsha Gowda, Vani Santosh, David Sid PROTEOMICS.2015; 15(2-3): 383. CrossRef - Prognostic Value of Ezrin in Various Cancers: A Systematic Review and Updated Meta-analysis
Jianwei Li, Kuanhai Wei, Hailang Yu, Dan Jin, Gang Wang, Bin Yu Scientific Reports.2015;[Epub] CrossRef - Radixin Enhances Colon Cancer Cell Invasion by Increasing MMP-7 Production via Rac1-ERK Pathway
Qi-Hong Jiang, Ai-Xiang Wang, Yan Chen The Scientific World Journal.2014; 2014: 1. CrossRef - Clinical significance of microRNA-183/Ezrin axis in judging the prognosis of patients with osteosarcoma
Yisila Mu, Haoshaqiang Zhang, Lixin Che, Kun Li Medical Oncology.2014;[Epub] CrossRef - Prognostic implications of ezrin and phosphorylated ezrin expression in non-small cell lung cancer
Tiefeng Jin, Jingchun Jin, Xiangyu Li, Songnan Zhang, Yun Ho Choi, Yingshi Piao, Xionghu Shen, Zhenhua Lin BMC Cancer.2014;[Epub] CrossRef - Prognostic Value of Ezrin in Solid Tumors: A Meta-Analysis of the Literature
Kun Han, WeiXiang Qi, ZhiHua Gan, Zan Shen, Yang Yao, DaLiu Min, Yves St-Pierre PLoS ONE.2013; 8(7): e68527. CrossRef
- Detection of BRAFV600E Mutations in Papillary Thyroid Carcinomas by Peptide Nucleic Acid Clamp Real-Time PCR: A Comparison with Direct Sequencing
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Dongjun Jeong, Yujun Jeong, Sungche Lee, Hyeran Lee, Wanju Lee, Hyungjoo Kim, Doosan Park, Soyoung Park, Wenxia Mu, Hyun-Deuk Cho, Mee-Hye Oh, Sung Soo Lee, Seung-Ha Yang, Chang-Jin Kim
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Korean J Pathol. 2012;46(1):61-67. Published online February 23, 2012
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DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.61
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9,773
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- Background
Papillary thyroid carcinoma (PTC) of the thyroid is the most common endocrine malignancy. High prevalence of an activating point mutation of BRAF gene, BRAFV600E, has been reported in PTC. We assessed the efficiency of peptide nucleic acid clamp real-time polymerase chain reaction (PNAcqPCR) for the detection of BRAFV600E mutation in PTC in comparison with direct sequencing (DS). MethodsA total of 265 thyroid lesions including 200 PTCs, 5 follicular carcinomas, 60 benign lesions and 10 normal thyroid tissues were tested for BRAFV600E mutation by PNAcqPCR and DS. ResultsThe sensitivity and accuracy of the PNAcqPCR method were both higher than those of DS for the detection of the BRAFV600E mutation. In clinical samples, 89% of PTCs harbored the BRAFV600E mutation, whereas 5 follicular carcinomas, 50 benign lesions and 10 normal thyroid tissues lacked the mutation. The mutation was associated with aggressive clinical behaviors as extrathyroid invasion (p=0.015), lymph node metastasis (p=0.002) and multiple tumor numbers (p=0.016) with statistical significance. ConclusionsThe PNAcqPCR method is efficiently applicable for the detection of the BRAFV600E mutation in PTCs in a clinical setting.
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